Introduction Yet the first recorded evidence of blood

Introduction Any mention of important medical advancements in the last millennium should acknowledge and shed some light onto the impact blood donation, or more specifically, blood component therapy has on the modern medical world. The significance of this being that the blood donated by one person can be separated into its components and used to benefit several patients rather than the one and ensures blood centres have all the blood types and the blood components to provide for the patients. This review explores the range of the cells produced by the hemopoietic system and how this system directly effects which blood products a person needs to treat certain diseases. Yet in doing so introduces the rare risks associated with this procedure and the way public health approaches these issues.  History Although processes like bloodletting has been performed from the time of Hippocrates the transfer of blood from one organism to another was first recorded in the mid seventeenth century. In 1666 written evidence was shown of transferring the blood of one animal into another and then the blood of an animal to a human at Oxford. This caused many fatalities due to ABO blood types not being discovered until over 230 years later by Karl Landsteiner, yet this showed people knew the importance of blood in medical procedures. The discoveries made in the following years then contributed to the first blood donor service in the world opening in 1921. Yet the first recorded evidence of blood component therapy was in 1940 when Edwin Cohn developed a method of separating the blood plasma in the blood to use for world war 2 victims. He and his team then went on to develop the first blood cell separator which separated blood into its components: red blood cells, white blood cells, plasma and platelets in the 1950s.      Blood components  Blood consists of a mixture of cells, colloids and crystalloids which through procedures can be separated into components such as red blood cell concentrates, platelet concentrate, fresh frozen plasma and cryoprecipitate. Each can have different uses depending on the patient receiving the components and the need for the use. Apheresis  These blood components are made through the hemopoietic system. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127320/  Red blood cell concentrate, red blood cell concentrates are packed red blood cells typically used to treat anaemic patients or patients with a severe lack of oxygen being transported around the body. RBC concentrates change in the number of residual platelets, plasma and additive solution, but this does not influence the efficiency of the blood transfer. The RCA have active constitutes of Erythrocytes which are cells that specialise at being haemoglobin carriers, and so respiratory gases can be transported and exchanged around the body. Erythrocytes can only survive in the blood for 21-35 days giving the blood component a strict shelf life if refrigerated.  Platelet have a vital role in the body by ensuring blood has the ability to clot. If the platelets count is below 10,000/?L than a transfusion may be required. Reasons for the low platelet count are most commonly due to diseases like Immune thrombocytopenia, dengue and certain types of cancer. Initially to improve platelet count doctors would transfer whole blood in the patient, which was first done in 1910 to help thrombocytopenia. However, in some cases the maximum shelf life of the platelets are only 72 hours at room temperature. Blood plasma make up 55% of the blood volume and is vital as it hold the blood cells in suspension. Blood plasma has to be frozen within 8 hours after collection and the when thawed to be used cannot be frozen again. The transfusion of blood plasma has been available since 1941 and was initially used as a volume replacement. Now generally it is used if a person’s blood has an inability to coagulate.   Cryoprecipitate is blood plasma with fibrinogen, von Willebrand factor, factor VIII, factor XIII and fibronectin. These clotting fibres appear when fresh frozen plasma is repeatedly frozen and thawed to get a higher concentration of these factors, and so Cryoprecipitate can be used to treat conditions such as fibrinogen deficiency. If frozen at –18 degrees Celsius then the shelf life can increase to a year.     The hemopoietic system are the series of organ that make the blood, and if there is a deficiency of a component, these organs replenish the cells. In embryos blood cell production occurs first in the yolk sac, then the liver and finally in the bone marrow. Part of the system includes the hematopoietic stem cells (HSC) these cells cell isolated  

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