Polymeric a period of time6 For this reason,

Polymeric nanoparticles
(NPs) are colloidal carriers into which drugs are loaded in either solid state
or solution, adsorbed non-covalently or chemically linked to the surface Polymeric
nanoparticles (NPs) are colloidal carriers into which drugs are loaded in
either solid state or solution, adsorbed non-covalently or chemically linked to
the surface.1  In recent times,
PNPs are extensively employed as biomaterials because of their favourable
characteristics in terms of simple elaboration and design, good
biocompatibility, a broad structures variety and noticeable bio-imitative
characteristics. Expressly in smart drug delivery discipline, PNPs had a marked
role as they are able to bring therapeutics right into the purposed position in
human body, with excellent efficiency2. Polymeric NPs have been used
as a preferred nanoscale drug delivery vehicle especially for their excellent
endocytosis efficiency, passive tumor-targeting, high encapsulation efficiency,
and delivery of a wide range of therapeutic agents3.   These
Np possess some advantages with respect to single molecules of drugs or
prodrugs, such as their high drug-loading capacity. It is, therefore, possible
to deliver a great number of drug molecules into cells for each Np. In
addition, Np provide protection to the embedded drugs against chemical or
enzymatic degradation thus increasing the chances of the active molecule
reaching the target site. Furthermore, it is possible to modify the Np surface
properties in order to facilitate drug delivery, for example, escape from the
RES system4.  Several
polymers have been used to produce NPs for CNS delivery using different
preparation techniques depending on polymer and drug features. Interestingly,
aiming to increase their circulation lifetime and improve drug delivery across
BBB, NPs surface properties can be modified by either adsorption or chemical
grafting of polyethylene glycol (PEG), poloxamers or other molecules, that
increase their circulation lifetime and improve drug delivery across the BBB.5 As
a result of the diversity of polymers, polymeric nanoparticles can be designed
to achieve desired properties such as controlled and/or sustained drug release
profile, as well as allowing drug release at the targeted site over a period of
time6

For this reason, a
variety of polymers have been investigated to form nanoparticles for brain drug
delivery.

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