[WU1]According of an APIs like polymorphs, salts, hydrates
to the previous sentence, polymorphic form of ambiciline should be compared
with other forms of ampicilin only not with nirofurantoin.
means? Generally in drug industry, their main task is to achieve the low drug
concentrations to reduce adverse and toxic effects.
should be a space between the references and the next sentence.
important step in the drug development is the selection of the appropriate
solid form for an active pharmaceutical component (API). Different forms of an
APIs like polymorphs, salts, hydrates and solvates may be selected for drug developmentref. The different forms of API acquires different
physicochemical properties such as solubility, dissolution rate, hygroscopicity,
stability, and mechanical properties.3 For example, the
chemical stability of ampicillin and nitrofurantoin (model drugs selected for
the study) is dependent on the solid-state form ref.
of ampicillin and nitrofurantoin exhibit different bioavailability issues due
to different solubility and dissolution rates of the solid formsref.WU1 Polymorphs of a compound exhibit different bioavailability
issues due to different solubility and dissolution rates of the solids forms.
Salt form of poorly soluble drugs (such as nitrofurantoin and acetaminophen etc)
increases its solubility and bioavailability.4,5 Amorphous
phases of APIs also permit to achieve high drug concentrations.6 WU2 Amorphous phases of APIs also permit to achieve high drug solubility.6 However, due to high reactivity, they are more liable
to physical and chemical instability than the crystalline phases.7–9 Solvates and hydrates
of an API similarly affect the biopharmaceutical properties of an API.10
Solvates have higher aqueous solubility, whereas hydrates have lower aqueous
solubility compared to anhydrous crystalline phases.11–14 As a
result, different forms of APIs can influence the biopharmaceutical properties
of one another. Researchers primarily prefer crystalline forms of their API, primarily
due to the underlying stability of crystalline matter and the well-established effects
of crystallization processes on the purification and isolation of chemical